Screening of anti-dengue activity in methanolic extracts of medicinal plants
Identifieur interne : 001198 ( Main/Exploration ); précédent : 001197; suivant : 001199Screening of anti-dengue activity in methanolic extracts of medicinal plants
Auteurs : Leon Ic Tang [Malaisie] ; Anna Pk Ling [Malaisie] ; Rhun Y. Koh [Malaisie] ; Soi M. Chye [Malaisie] ; Kenny Gl Voon [Malaisie]Source :
- BMC Complementary and Alternative Medicine [ 1472-6882 ] ; 2012.
Abstract
Dengue fever regardless of its serotypes has been the most prevalent arthropod-borne viral diseases among the world population. The development of a dengue vaccine is complicated by the antibody-dependent enhancement effect. Thus, the development of a plant-based antiviral preparation promises a more potential alternative in combating dengue disease.
Present studies investigated the antiviral effects of standardised methanolic extracts of
The methanol extracts of
Url:
DOI: 10.1186/1472-6882-12-3
PubMed: 22244370
PubMed Central: 3269354
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Screening of anti-dengue activity in methanolic extracts of medicinal plants</title><author><name sortKey="Tang, Leon Ic" sort="Tang, Leon Ic" uniqKey="Tang L" first="Leon Ic" last="Tang">Leon Ic Tang</name><affiliation wicri:level="1"><nlm:aff id="I1">School of Medical Sciences, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ling, Anna Pk" sort="Ling, Anna Pk" uniqKey="Ling A" first="Anna Pk" last="Ling">Anna Pk Ling</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Rhun Y" sort="Koh, Rhun Y" uniqKey="Koh R" first="Rhun Y" last="Koh">Rhun Y. Koh</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Chye, Soi M" sort="Chye, Soi M" uniqKey="Chye S" first="Soi M" last="Chye">Soi M. Chye</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Voon, Kenny Gl" sort="Voon, Kenny Gl" uniqKey="Voon K" first="Kenny Gl" last="Voon">Kenny Gl Voon</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22244370</idno><idno type="pmc">3269354</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3269354</idno><idno type="RBID">PMC:3269354</idno><idno type="doi">10.1186/1472-6882-12-3</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000D98</idno><idno type="wicri:Area/Pmc/Curation">000D97</idno><idno type="wicri:Area/Pmc/Checkpoint">000C24</idno><idno type="wicri:Area/Ncbi/Merge">000E80</idno><idno type="wicri:Area/Ncbi/Curation">000E80</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E80</idno><idno type="wicri:Area/Main/Merge">001210</idno><idno type="wicri:Area/Main/Curation">001198</idno><idno type="wicri:Area/Main/Exploration">001198</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Screening of anti-dengue activity in methanolic extracts of medicinal plants</title><author><name sortKey="Tang, Leon Ic" sort="Tang, Leon Ic" uniqKey="Tang L" first="Leon Ic" last="Tang">Leon Ic Tang</name><affiliation wicri:level="1"><nlm:aff id="I1">School of Medical Sciences, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>School of Medical Sciences, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Ling, Anna Pk" sort="Ling, Anna Pk" uniqKey="Ling A" first="Anna Pk" last="Ling">Anna Pk Ling</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Koh, Rhun Y" sort="Koh, Rhun Y" uniqKey="Koh R" first="Rhun Y" last="Koh">Rhun Y. Koh</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Chye, Soi M" sort="Chye, Soi M" uniqKey="Chye S" first="Soi M" last="Chye">Soi M. Chye</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Human Biology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author><author><name sortKey="Voon, Kenny Gl" sort="Voon, Kenny Gl" uniqKey="Voon K" first="Kenny Gl" last="Voon">Kenny Gl Voon</name><affiliation wicri:level="1"><nlm:aff id="I3">Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur, Malaysia</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea>Department of Pathology, Faculty of Medicine and Health, International Medical University, Bukit Jalil, Kuala Lumpur</wicri:regionArea><wicri:noRegion>Kuala Lumpur</wicri:noRegion></affiliation></author></analytic><series><title level="j">BMC Complementary and Alternative Medicine</title><idno type="eISSN">1472-6882</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Dengue fever regardless of its serotypes has been the most prevalent arthropod-borne viral diseases among the world population. The development of a dengue vaccine is complicated by the antibody-dependent enhancement effect. Thus, the development of a plant-based antiviral preparation promises a more potential alternative in combating dengue disease.</p></sec><sec><title>Methods</title><p>Present studies investigated the antiviral effects of standardised methanolic extracts of <italic>Andrographis paniculata, Citrus limon, Cymbopogon citratus, Momordica charantia, Ocimum sanctum </italic>and <italic>Pelargonium citrosum </italic>on dengue virus serotype 1 (DENV-1).</p></sec><sec><title>Results</title><p><italic>O. sanctum </italic>contained 88.6% of total flavonoids content, an amount that was the highest among all the six plants tested while the least was detected in <italic>M. charantia</italic>. In this study, the maximum non-toxic dose (MNTD) of the six medicinal plants was determined by testing the methanolic extracts against Vero E6 cells <italic>in vitro</italic>. Studies also determined that the MNTD of methanolic extract was in the decreasing order of <italic>M. charantia </italic>><italic>C. limon </italic>><italic>P. citrosum, O. sanctum </italic>><italic>A. paniculata </italic>><italic>C. citratus</italic>. Antiviral assay based on cytopathic effects (CPE) denoted by degree of inhibition upon treating DENV1-infected Vero E6 cells with MNTD of six medicinal plants showed that <italic>A. paniculata </italic>has the most antiviral inhibitory effects followed by <italic>M. charantia</italic>. These results were further verified with an <italic>in vitro </italic>inhibition assay using MTT, in which 113.0% and 98.0% of cell viability were recorded as opposed to 44.6% in DENV-1 infected cells. Although methanolic extracts of <italic>O. sanctum </italic>and <italic>C. citratus </italic>showed slight inhibition effect based on CPE, a significant inhibition was not reflected in MTT assay. Methanolic extracts of <italic>C. limon </italic>and <italic>P. citrosum </italic>did not prevent cytopathic effects or cell death from DENV-1.</p></sec><sec><title>Conclusions</title><p>The methanol extracts of <italic>A. paniculata </italic>and <italic>M. charantia </italic>possess the ability of inhibiting the activity of DENV-1 in <italic>in vitro </italic>assays. Both of these plants are worth to be further investigated and might be advantageous as an alternative for dengue treatment.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Halstead, Sb" uniqKey="Halstead S">SB Halstead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guzman, Mg" uniqKey="Guzman M">MG Guzman</name></author><author><name sortKey="Kouri, G" uniqKey="Kouri G">G Kouri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibbons, Rv" uniqKey="Gibbons R">RV Gibbons</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gubler, Dj" uniqKey="Gubler D">DJ Gubler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murrell, S" uniqKey="Murrell S">S Murrell</name></author><author><name sortKey="Wu, Sc" uniqKey="Wu S">SC Wu</name></author><author><name sortKey="Butler, M" uniqKey="Butler M">M 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name="Malaisie"><noRegion><name sortKey="Tang, Leon Ic" sort="Tang, Leon Ic" uniqKey="Tang L" first="Leon Ic" last="Tang">Leon Ic Tang</name></noRegion><name sortKey="Chye, Soi M" sort="Chye, Soi M" uniqKey="Chye S" first="Soi M" last="Chye">Soi M. Chye</name><name sortKey="Koh, Rhun Y" sort="Koh, Rhun Y" uniqKey="Koh R" first="Rhun Y" last="Koh">Rhun Y. Koh</name><name sortKey="Ling, Anna Pk" sort="Ling, Anna Pk" uniqKey="Ling A" first="Anna Pk" last="Ling">Anna Pk Ling</name><name sortKey="Voon, Kenny Gl" sort="Voon, Kenny Gl" uniqKey="Voon K" first="Kenny Gl" last="Voon">Kenny Gl Voon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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